The factors for the early and late development of midbrain dopaminergic neurons segregate into two distinct evolutionary clusters

• Midbrain dopaminergic neuron transcription factors modulate the long-term survival and maintenance of these neurons. Understanding developmental pathways might lead to a better insight into their degeneration in Parkinson's disease. Phylogenetic profiling was used identify molecular interactions correlated with factors. Two distinct evolutionary pathways, pertaining early late novel links were identified. The shed light on causes vulnerability midbrain neurons are responsible for several functions reward system, control emotion, motivation, cognition, motor behavior. A set well-characterized involved specification, neurogenesis, neuronal differentiation determines fate modulates postnatally. Identifying connections might, therefore, understanding physiology as well dysfunction To explore between linkages, we examined correlations phylogenetic profiles those entire human proteome. Our analysis revealed two comprising new linkages cascades. These results suggest an scenario development neurons, potential canonical non-canonical